Open access
Jul 2026
ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-Enhancer in Acute Lymphoblastic Leukemia.
It is demonstrated that ETV6 functions as a regulatory element via ETV6-SE in ALL, with CDKN1B as a key target and CRISPR interference and knockout experiments revealed the core enhancer region within ETV6-SE responsible for CDKN1B regulation.
Wenqian Xu, Xiaofang Ma, Xue Sun et al.
· Cancer Research · 0 citations