Protein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.
Protein phosphatase 2A, a serine-threonine phosphatase, plays a pivotal role in diverse cellular processes in eukaryotic cells. In this research, we observed a significant increase in PP2Ac expression in NPCs with higher degeneration grades. In vitro experiments demonstrated that following the induction of NP cell dege...