Abstract Antibiotic exposure is a major driver of gut microbiota dysbiosis, and its effects extend beyond transient diversity loss. Persistent alterations in microbial composition and metabolites disrupt intestinal barrier integrity, immune homeostasis, and host metabolic signaling, thereby increasing the risk of chron...
Hang Guo, Cheng-Cheng Zhang, Rui-Min Wang et al.· Gut microbes· 0 citations
The microbiota and metabolic dysbiosis underlying flatulence is revealed, the key regulatory role of F. prausnitzii is highlighted, and the foundation for targeted microbiota-based intervention strategies for flatulence is laid.
Rui-Min Chen, Chuan Zhang, Shi-Kai Yan et al.· Gut microbes· 0 citations
It is demonstrated that Lamtor5 ablating macrophages displayed senescent signatures, metabolic defects, aging-related transcriptomic and epigenetic features, nicely concurring with macrophages from naturally aging mice, opening a new avenue for developing macrophage-based therapeutics to improve healthy aging.
Nianyin Lv, Yunzhe Tang, Wei Zhang et al.· Cell Death and Differentiati...· 0 citations
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