Integrative multi-omics analysis reveals LLPS-associated CLEC2D⁺AR⁻ tumor-cell states linked to early adaptive progression toward castration resistance in prostate cancer
Findings provide a conceptual link between LLPS biology, AR-independent tumor-cell plasticity, and microenvironmental remodeling in CRPC, while nominating CLEC2D as a candidate marker and potential therapeutic target requiring further experimental validation.