Shu-Mu Zheng

Narirutin mitigates osteoarthritis by targeting USP15 to promote KEAP1 degradation and suppress chondrocyte ferroptosis.

BACKGROUND Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage degeneration and joint dysfunction, for which effective therapeutic options remain limited. Increasing evidence suggests that ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxi...