Author

Shuqian Xu

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Open access Sep 2026

Lysophosphatidylcholine-induced macrophage polarization imbalance and functional dysregulation in immune thrombocytopenia.

BACKGROUND The pathogenesis of immune thrombocytopenia (ITP) involves platelet destruction driven by immune dysregulation, notably macrophage dysfunction. Lysophosphatidylcholine (LPC), a class of bioactive lipid, can modulate inflammation and immunity. This study aimed to determine whether LPC (16:0/0:0) reprograms ma...

Nan Jiang, Zi Sheng, Shao-Qiu Leng et al. · Chinese Medical Journal · 0 citations

Open access Sep 2026

GTPase RAB31 supports ANXA1-driven macrophage education through clathrin-mediated endocytosis to suppress antitumor immunity

Findings establish the CME/RAB31 pathway as an indispensable regulator of TAM polarization, underscoring the pivotal role of vesicular trafficking in the TME.

Jing-Jing Liu, Shan-Shan Wang, Deng-Yi Bao et al. · Journal for ImmunoTherapy of... · 0 citations

Aug 2026

Reduced SRSF1 Expression Correlates with LCK Exon Skipping and Impaired Treg Induction in Immune Thrombocytopenia.

Findings define a novel SRSF1-LCK splicing axis that may regulate Treg development in ITP and identify the splicing factor SRSF1 as a direct upstream regulator of LCK exon 8 skipping.

Xiang Hu, Shaoqiu Leng, Yan Liu et al. · Blood · 0 citations