Author

Shu-Qun Cheng

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Jul 2026

ARID1A Stimulates Notch-TLL1 Signaling to Induce Cancer-Associated Fibroblast Activation and Intrahepatic Cholangiocarcinoma Development.

Intrahepatic cholangiocarcinoma (ICC) is a lethal hepatic malignancy characterized by a prominent desmoplastic stroma. Here, we demonstrated that ARID1A, a core component of the SWI/SNF protein complex, is upregulated in ICC and plays an oncogenic role. Mechanistically, ARID1A stabilized NICD1 protein by inhibiting AMP...

Sheng Xu, Jing-Yi Huang, Kang Wang et al. · Cancer Research · 0 citations

Open access Jul 2026

DCAF13: a positive regulator of colon cancer cell proliferation via the AMER2/ Wnt/β-catenin pathway.

In colon cancer cells, DCAF13 regulated adenomatous polyposis coli membrane recruitment 2 (AMER2) through ubiquitination, DCAF13 deletion increased AMER2 expression, which inhibited Wnt/β-catenin activity, suppressing cell proliferation, and this effect was further validated in mice with gut-specific DCAF13 knockout.

Yu-Xin Hua, Jie Gao, Qing Sun et al. · npj Precision Oncology · 0 citations