Author

Shu-Rui Yan

2 papers indexed here

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Open access Jul 2026

Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers.

A first-in-class small-molecule inhibitor is identified that blocks E7-ZER1 association, restores Rb stability, and selectively suppresses HPV-positive tumor growth in vivo and nominate the ZER1 degron pocket as a ligandable therapeutic target for HPV-driven malignancies, highlighting translational opportunities for ta...

Xiao-Lu Wang, Chenhao Jiang, Yue-Ling Zhao et al. · Cell Reports · 0 citations

Open access Aug 2026

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N6-methyladenosine (m6A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved in the pathogenesis of CRLM. Precise manipula...

Xue-Na Chen, Shu-Qiang Zhao, Bochen Liu et al. · Molecular Cancer · 0 citations