Author

Shuyan Yu

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Open access Oct 2026

PPAR-γ/SGK1/GSK3β/Nrf2 signaling pathway contributes to the neuroprotective effects of lycopene in depressed mice.

INTRODUCTION Major depressive disorder (MDD) is a neuropsychiatric disorder associated with abnormal neuronal activity in specific brain regions. Recent evidence suggests that oxidative stress- and neuroinflammation-driven impairments in synaptic structure and neuronal function may contribute to depression, yet the pre...

Yong-Si Zhao, Meng-Ni Chang, Cheng-Xin Hu et al. · Journal of Advanced Research · 0 citations

Oct 2026

Deficiency of Synaptotagmin 9 in the Hippocampal Region Induces Synaptic Damage and Cognitive Impairment in Parkinson's Disease Mice via BDNF/TrkB Signaling.

Cognitive impairment is a prominent non-motor symptom of Parkinson's disease (PD) that severely affects patients' quality of life, yet its underlying molecular mechanisms remain incompletely understood. Here, we investigated the role of hippocampal Synaptotagmin 9 (Syt9) in PD-related cognitive deficits. We found that...

Ning Xu, Chen-Chen Du, Yi-Le Li et al. · Neuropharmacology · 0 citations

Open access Jul 2026

The Wnt signaling regulator Dkk3 improves neural-activity homeostasis to prevent stress-induced anxiety disorder.

OBJECTIVES The medial prefrontal cortex (mPFC) is a cortical brain region that involved in various emotional disorder. Neuroinflammation and oxidative stress are reported to associated with the pathogenesis of anxiety, but the underlying brain mechanisms remain unclear. METHODS AND RESULTS Here, using a mouse model o...

Xiao Chen, Ruojing Guo, Changmin Wang et al. · Journal of Advanced Research · 0 citations