Metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasingly linked to environmental chemical exposure, yet the metabolic consequences of pesticide parent-metabolite co-exposure remain poorly understood. HepG2 cells were exposed for 48 h to chlorpyrifos (CPF, 10 mg/L), its major metabolite 3,5...
Qing-Yang Li, Wei Zhu, Xiao-Meng Han et al.· Ecotoxicology and Environmen...· 0 citations
Diazepam (DZP) is a widely prescribed benzodiazepine that is increasingly detected in aquatic systems and known to impair neural function in aquatic organisms. However, its potential to elicit intergenerational neurobehavioral disruption, along with the underpinning mechanism in fish, remains uncharacterized. In this s...
Accurately predicting the acute toxicity of chemicals to Daphnia magna is critical for environmental risk assessment. Yet, current deep learning models often exhibit limited generalization and overconfidence when processing out-of-distribution molecules, risking dangerous false-negative errors due to scarce training da...
Ze-Xin Wen, Rong Yang, Rui-Dong Chen et al.· Environmental Pollution· 0 citations
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