Review
Open access
Aug 2026
IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions
Colitis-associated cancer (CAC) develops within chronically inflamed mucosa and differs from sporadic colorectal cancer in its field effects, multifocality, and sequence of molecular events. In addition to ongoing inflammation and mutation, experimental studies indicate that epithelial, immune, and stromal compartments...
Guo-Jun Gao, Xin Zhao, Xin Lu et al.
· Frontiers in Immunology · 0 citations