Shuai Guo

Advances in RNA delivery to extrahepatic tissues and cells.

This review critically examines recent progress in engineering delivery systems to access representative extrahepatic tissues, including the central nervous system (CNS), eye, lung, heart, spleen, inner ear, and bone marrow, and evaluates the rational design of viral vectors, polymeric and lipid-based nanocarriers, exosome platforms, hydrogel depot systems, and local administration strategies that bypass systemic clearance.