Shuai-Jie Guo

Guanxinkang Decoction and Its Key Component Isotanshinone II Ameliorate Atherosclerosis Through Modulation of STAT3/ CD36 Signaling and Macrophage Efferocytosis: An Integrated Network Pharmacology and Experimental Validation Study.

INTRODUCTION To investigate the potential anti-atherosclerotic mechanisms of Guanxinkang (GXK), with emphasis on its association with STAT3/CD36 pathway regulation and efferocytosis-related signaling. METHODS Network pharmacology identified key targets, which were validated by molecular docking and dynamics simulatio...