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Open access Sep 2026

Tailoring lipid nanoparticles for application-specific mRNA delivery.

Expanding the therapeutic landscape of mRNA medicines to diverse applications necessitates delivery systems tailored to distinct biological requirements. However, beyond vaccine applications, current FDA-approved lipid nanoparticles (LNPs) are often directly used as their original vaccine formulations, substantially li...

Xin-Xin Yan, Li-Xin Lin, Yi-Fan Zhang et al. · 0 citations
Jul 2026

Decoding the Functional Roles of Individual Components in mRNA Lipid Nanoparticles.

Lipid nanoparticles (LNPs) have represented a leading platform for mRNA delivery and therapeutics. While extensive studies have focused on optimizing ionizable lipids, the specific roles of helper lipids such as cholesterol, phospholipid, and polyethylene glycol lipid (PEG-lipid) remain relatively poorly understood. To...

Kexin Su, Zichuan Wang, Lu Shi et al. · 0 citations

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