Author

Shuang Chai

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Open access Oct 2026

Elucidation of the potential mechanisms of di-2-ethylhexyl phthalate (DEHP)-associated osteoporosis by integrating network toxicology and in vitro validation.

Di-2-ethylhexyl phthalate (DEHP) is a plasticizer widely used in daily life and is known for its toxicity after exposure. However, its toxic effects and mechanisms in Osteoporosis (OP) have not been fully explored. This work explored the potential mechanisms of DEHP-associated OP by integrating network toxicology, mole...

Bo Lu, Xu-Wang Gao, Shuang Chai et al. · Ecotoxicology and Environmen... · 0 citations

Open access Sep 2026

Integrative network toxicology, molecular docking, and in vitro experiments identify SLC6A2 as a novel candidate target in nicotine-induced osteoporosis.

In recent years, the health problems attributable to cigarette smoke (CS) have attracted widespread attention. However, the pathogenic mechanisms underlying osteoporosis development induced by nicotine, a neuroactive component of CS, remain unclear. In this study, we examined a potential molecular mechanism underlying...

Bo Lu, Xu-Wang Gao, Qian Wang et al. · Experimental Gerontology · 0 citations