Chronic inflammatory diseases caused by bacterial infections are notoriously difficult to treat due to the formation of a vicious cycle in which bacterial infection and immune dysregulation mutually reinforce each other at the lesion site. Current antibiotic therapies face the dual challenges of escalating drug resis...
Xiao-Peng Zhou, Hua-Fu Wang, Shuang-Hua Wang et al.· ACS Omega· 0 citations
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with limited treatment options and poor prognosis due to the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2). Doxorubicin (DOX)-based chemotherapy remains the standard of care, y...
Wei Song, Zhong-Xin Liu, Jia Xu et al.· Bio-Design and Manufacturing· 1 citation
A RVG‐modified liposomal nanoplatform for targeted delivery of mollugin (Mol@Lip‐RVG) as a novel therapeutic strategy for SCI resulted in enhanced neuro‐preservation and substantial improvement in motor function recovery, achieved through dual modulation of microglial reprogramming and attenuation of oxidative stress.
Quan Zhou, I. Shaikh, Jian-Feng Wang et al.· Advanced Healthcare Material...· 0 citations
This study showed that mucoadhesive polymeric nanoparticles of vonoprazan significantly enhanced solubility, pH-dependent release, and improved mucoadhesion, making it a promising approach to improve the oral bioavailability of drugs with poor water solubility.
S. Sajjad, U. Tulain, M. Asim et al.· International Journal of Nan...· 0 citations
Overall, the PEG (HEMA-co-AA) hydrogel represents a versatile vehicle for the controlled and local administration of acid-labile pharmaceuticals, thereby promoting increased therapeutic efficacy and safe for use in future therapeutic applications.
U. Tulain, N. Malik, Alia Erum et al.· Journal of Pharmacy and Scie...· 0 citations
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