Author

Shuang Jia

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Review Open access Sep 2026

Engineering TnpB as a compact RNA-guided genome editor from molecular constraints to design principles

Recent discoveries of non-CRISPR RNA-guided nucleases have expanded the landscape of programmable genome editing beyond canonical Cas systems. Among these, TnpB proteins derived from IS200/IS605-family transposable elements are ultra-compact RNA-guided DNA endonucleases with potential for delivery-constrained genome en...

Bin Ma, Yi-Miao Li, Dong-Sheng Zhang et al. · Frontiers in Genome Editing · 0 citations

Open access Sep 2026

A native single-transcript TnpB architecture enables efficient virus-induced genome editing and visual screening of heritable progeny harboring phenotypically silent edits

TnpB are ultra-compact RNA-guided nucleases, yet most reported systems require separate expression of the nuclease and cognate reRNA, eroding their size advantage and restricting viral delivery in plants. Here we demonstrate that ISDra2 TnpB harnesses its native overlapping architecture in which the reRNA sequence resi...

Rui Wang, Hong-Fei Liu, Shuang Jia et al. · bioRxiv · 0 citations

Open access Aug 2026

Application of a Bioactive Compound 2,4-Di-tert-butylphenol in Nanoemulsion Form for Shelf-Life Extension of Cherry Tomatoes: From Microbial Inactivation to Quality and Safety Evaluation

Postharvest spoilage of cherry tomatoes caused by pathogenic microorganisms and oxidative browning leads to significant economic losses and food waste. Natural bioactive compounds are gaining increasing attention as alternatives to synthetic pesticides. In this study, a nanoemulsion (NED) formulation of nature-derived...

Yan-Xin Zhang, Hui Li, Chenxvan Yan et al. · Foods · 0 citations