Metabolic-reprogrammed MnO₂-Mg/Pt@BBF nanozyme disrupts biofilm cohesion for enhanced chemodynamic therapy of periodontitis.
OBJECTIVES To overcome the intrinsic incompatibility between dense periodontal biofilms and chemodynamic therapy (CDT), we developed a vacancy-engineered MnO₂ nanozyme that integrates redox-state programming, Mg²⁺-enabled endogenous H₂O₂ amplification, and covalently immobilized quorum-sensing inhibition for the local...