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Open access Jul 2026

CAPNS1 restoration partially alleviates mitochondrial dysfunction and synaptic deficits in Alzheimer's disease through the Ca2⁺-CaMKIIβ-MAPK-PGC-1α axis.

Significantly, neuronal-specific CAPNS1 upregulation in APP/PS1 transgenic mice markedly improved mitochondrial cristae integrity, reversed hippocampal long-term potentiation deficits, increased dendritic spine density, and partially alleviated spatial memory deficits in behavioral tests.

Jia-Lin Han, Shuang Wu, Xiaolin Cui et al. · 0 citations

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