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Author

Shuangjia Lu

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Open access Jul 2026

HPRC2: A human pangenome reference with near-complete coverage of common genetic variation

The Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2) is presented, an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in genome completeness, contiguity, and accuracy.

Julian K. Lucas, Prajna Hebbar, Wen-Wei Liao et al. · 6 citations
Open access Jul 2026

Pangenome-based human genome analysis improves trait association and genomic prediction

A graph-based method for associating sequence variation with traits using short-read genome sequencing data, and shows that it captures complex forms of genetic variation missed by other methods, suggest that integration of pangenomic methods into human genetic studies will improve trait association and genomic predict...

Shuangjia Lu, Wen-Wei Liao, Marianne K. DeGorter et al. · 0 citations

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