Shubham Kumar Sharma

Interplay of Depletion Interaction and Viscosity Drives Non-monotonic Ligand Binding to DNA G-Quadruplex under Crowding

Study of ligand binding to G-quadruplex (G4) DNA under molecular crowding is essential for understanding its implications in cellular contexts; however, the underlying mechanism remains largely unresolved. We investigate the binding of 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPy...