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Author

Shuchun Xie

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Open access Aug 2026

Integrative single-cell sequencing and machine learning analyses identify chronic inflammation and cancer-associated fibroblast subsets as drivers of adverse outcomes in ovarian cancer

Highlights • Single-cell analysis identifies M8 fibroblast subcluster as dominant post-NACT population linked to ovarian cancer chemo-resistance.• NHP2 shows high diagnostic value (AUC=0.758) and predicts poor survival, driving ovarian cancer progression.• NHP2 knockdown suppresses proliferation, migration and invasion...

Mingqin Kuang, Chang-Mei Shen, Chun-Ping Yang et al. · 0 citations

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