Author

S. Yao

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Sep 2026

Intelligent programmable droplet with deterministic cell control for quantitative single-cell metabolic analysis.

Single-cell metabolic heterogeneity influences cell state, disease progression, and therapeutic response, yet quantitative metabolic analysis remains constrained by stochastic cell loading and uncertain droplet occupancy. Here, we developed an intelligent programmable droplet microfluidic platform (ProgDrop-Met) that i...

Zhi-Hang Yu, Zhen-Ye Sheng, Yi-Ke Cai et al. · Biosensors & bioelectronics · 0 citations

Open access Jul 2026

RAPID: evaluation of Cas12a protospacer nicking and chimeric reporters for PAM-independent RNA and DNA diagnostics

RAPID (RNA/DNA Advanced chimeric, PAM-independent, Integrated Nicking, Diagnostics), a nick-tuned, PAM-duplex-mediated platform for PAM-independent RNA and DNA detection and applies it to detect single-point mutations in ssDNA and RNA substrates, a challenge for traditional Cas12 and Cas13 systems.

I. Iwe, Frank X. Liu, A. Corsano et al. · Nucleic Acids Research · 0 citations