X-ray-Responsive Cascade System for Radioimmunotherapy: Tumor Microenvironment Remodeling and Controllable NO Release
Radioimmunotherapy holds great promise for the treatment of solid tumors. However, radioresistance and immunosuppression mediated by a tumor microenvironment (TME) severely restrict radiation-induced immunogenic cell death (ICD), facilitate tumor relapse and metastatic dissemination, and ultimately compromise the the...