Open access
Aug 2026
Hepatic Neu1 Deficiency Drives Metabolic Dysregulation via GCGR Desialylation-dependent cAMP-PKA Signaling and Inflammatory Response in Old Mice.
BACKGROUND Neuraminidase 1 (Neu1) plays a crucial role in the removal of sialic acid from glycoproteins and glycolipids, significantly influencing hepatic glycolipid metabolism. However, its precise contributions to liver gluconeogenesis and bile acid metabolism are not well defined. Although the sialylation of the hep...
Shiran Mei, Huiqin Hu, Guo-Xue Zhu et al.
· Molecular and Cellular Endoc... · 0 citations