Aug 2026
Discovery of novel Quinazoline-chalcone hybrids as dual VEGFR-2/P-gp inhibitors to reverse cisplatin resistance in cervical Cancer.
Mechanistic studies revealed that co-administration of 5n significantly restored HeLa/DDP cell sensitivity to cisplatin, reducing the RI of cisplatin from 6.07 to 1.49, outperforming the classical inhibitor, verapamil.
Tong Yan, Mutewaer Muhebuli, M. Ablise et al.
· Bioorganic chemistry (Print) · 0 citations