Osteosarcoma remains the most common primary malignant bone tumor, and survival has improved little over recent decades because of metastasis and therapeutic resistance. Flavones exhibit diverse anti-osteosarcoma activities by suppressing proliferation, inducing apoptosis, ferroptosis and autophagy, inhibiting metastas...
Ko-Hsiu Lu, Renn-Chia Lin, Meng-Ying Tsai et al.· Drug Discovery Today· 0 citations
Background: Nasopharyngeal carcinoma (NPC) is a highly metastatic epithelial malignancy with limited therapeutic options for advanced disease. Timosaponin AIII (TSAIII), a natural steroidal saponin, exhibits antitumor activity; however, its effects on NPC progression and the molecular mechanisms remain unclear. Method:...
Chu-Che Lee, Yong-Syuan Chen, Shun-Fa Yang et al.· Cells· 0 citations
Curcumin is a naturally occurring polyphenol extracted from turmeric (Curcuma longa) and is known for its diverse biological functions, such as antioxidant, anti-inflammatory, anti-migratory, and anticancer activities. However, its use in clinical cancer treatment remains constrained due to challenges like limited abso...
Shih-Chi Su, Chun-Wen Su, Chia-Yi Lee et al.· Archives of pharmacal resear...· 0 citations
The functional role of ACOT7 was examined using an integrated approach, combining analysis of clinical datasets with in vitro and in vivo experiments, and MYC-associated regulation and changes in total AKT and p-MDM2 levels suggest a potential connection between ACOT7 and growth-related signaling.
Zhen-Ning Jin, Jia-Yi Peng, Diana Messadi et al.· Cancer & Metabolism· 0 citations
Osteosarcoma is the most common primary malignant bone tumor and is associated with a high mortality rate due to its pronounced metastatic potential. Although tricin has been proposed as a chemosensitizer in various malignancies, its anti‐metastatic effect in osteosarcoma remains poorly characterized. This study invest...
Chia-Hsuan Chou, Jia-Sin Yang, Pei-Ni Chen et al.· Drug development research (P...· 0 citations
Specific ADs and MI share an immunogenetic architecture involving immune and vascular pathways involving immune and vascular pathways that warrant further mechanistic investigation.
Chung-Chih Liao, Wu Hu, Shun-Fa Yang et al.· Atherosclerosis· 0 citations
In vivo xenograft and experimental metastasis models validated that ESM1 depletion significantly impaired tumor growth and lung metastasis while increasing ID3 expression, identifying the ESM1/DNMT3A/ID3 axis as a novel epigenetic driver of cervical cancer and a potential therapeutic target.
Chen-Lin Yu, Chia-Liang Lin, Hsiang-Lin Lee et al.· Cell Death Discovery· 0 citations
IL31RA polymorphisms may be associated with an increased propensity for lymph node involvement, particularly in gingival cancer, suggesting that IL31RA may have potential clinical relevance in OCSCC progression.
