Shun-Li Fu

In vivo-edited CCR7+IL-7+ DCs reverse T cell exhaustion by promoting T memory stem cell differentiation.

T cell exhaustion presents a challenge for antitumor immunotherapy. T memory stem cells (Tscms), whose ability to self-renew can continuously generate effector T cells, offering a way to reverse T cell exhaustion. Here, we propose a Tscm regulation strategy involving the construction of dendritic cell (DC)-targeting CC...