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Shun-Yong He

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Open access Sep 2026

Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation

Background Microplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear. Methods We integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based functional association...

Li-Sha Lu, Yuan-Ming Yang, Shun-Yong He et al. · 0 citations
Oct 2026

miR-885-5p regulates fibrogenic phenotypes in TGF-β1-treated LX-2 cells via targeting NR5A2, with clinical association with MAFLD.

BACKGROUND Metabolic-associated fatty liver disease (MAFLD) is a common chronic liver disease worldwide, with liver fibrosis serving as a major determinant of poor prognosis. While miR-885-5p shows dysregulated expression in numerous metabolic and liver disorders, its function in MAFLD has yet to be fully elucidated. T...

Zi-Hui Yu, Rong Zhou, Shun-Yong He · 0 citations

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