Shuo-Chen Xu

Lead optimization of 3-indoleacetonitrile identifies candidate compounds with improved anti-influenza activity and safety profiles

Introduction Influenza A virus (IAV) remains a major respiratory pathogen that causes substantial morbidity, mortality, and socioeconomic burden worldwide. Although several antiviral agents are available for clinical use, their effectiveness is often compromised by the emergence of drug-resistant variants, limited ther...