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Open access Oct 2026

A Dual Mechanism-Based Physiologically Based Pharmacokinetic Model for Predicting Mitoxantrone and Liposomal Mitoxantrone Disposition: Preclinical Validation in Rats and Human Extrapolation with Clinical Evaluation

Purpose This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to quantitatively predict plasma and tissue concentrations of both liposomal-encapsulated and free mitoxantrone in rats and further extrapolate the model to human clinical scenarios. Methods A dual-compartment PBPK framework was co...

Yu-Xiang Xu, Shuo Li, Zhi-Xuan Yang et al. · 0 citations

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