Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...
Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al.· Journal of Chemical Physics· 0 citations
Neurons can maintain proteostasis by extruding protein aggregates and damaged organelles via large extracellular vesicles called exophers. However, the biophysical rules governing exopher cargo selection remain poorly understood. Here, we discovered that biomolecular condensates can localize to exophers and investigate...
Mayur Barai, E. Chuang, Shuo-Lin Weng et al.· bioRxiv· 0 citations
Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...
Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al.· bioRxiv· 0 citations
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