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Author

Shuo-Lin Weng

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Open access Sep 2026

Molecular origins of pH gradients in charge-regulated biomolecular condensates.

Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...

Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al. · 0 citations
Open access Aug 2026

Condensate Material Properties Influence Cargo Selection for Neuronal Extrusion via Large Extracellular Exopher Vesicles

Neurons can maintain proteostasis by extruding protein aggregates and damaged organelles via large extracellular vesicles called exophers. However, the biophysical rules governing exopher cargo selection remain poorly understood. Here, we discovered that biomolecular condensates can localize to exophers and investigate...

Mayur Barai, E. Chuang, Shuo-Lin Weng et al. · 0 citations
Open access Jul 2026

Molecular Origins of pH Gradients in Charge-Regulated Biomolecular Condensates

Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...

Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al. · 0 citations

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