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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Shuo Zhang

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Open access Sep 2026

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

ABSTRACT Mesenchymal stem cells (MSCs) are critical for bone regeneration, and their osteogenic and adipogenic lineage balance is intricately regulated by cellular mechanotransduction. Through single‐cell RNA sequencing reanalysis of the public dataset GSE166824, primary mouse MSC functional assays, and in vivo genetic...

Shuo Zhang, Si-Teng Li, Wen-Zhong Chen et al. · 0 citations
Open access Aug 2026

Dysregulated JAK2 signaling delays fracture healing by enhancing STAT3/NF-κB signaling and inhibiting BMP2-mediated osteogenesis.

These findings identify bidirectional JAK2 dysregulation as a potential mechanism linking metabolic dysfunction and sustained JAK2 activation to impaired bone regeneration andModulation of JAK2-mediated inflammatory signaling may represent a potential therapeutic approach to improve fracture repair in metabolic and hem...

Cheng Zhang, Xuebin Zhang, Yang Luo et al. · 0 citations
Book Open access Jul 2026

CKTI: A Domain-Specific Compiler for Lowering CUDA Kernels to Triton-IR

CKTI is introduced, a domain-specific compiler that lowers CUDA kernels to Triton-IR, thereby decoupling them from proprietary hardware and fostering diversity across the computing ecosystem.

Changqing Shi, Rui Chen, Yufei Sun et al. · 0 citations

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