The Wnt signaling regulator Dkk3 improves neural-activity homeostasis to prevent stress-induced anxiety disorder.
OBJECTIVES The medial prefrontal cortex (mPFC) is a cortical brain region that involved in various emotional disorder. Neuroinflammation and oxidative stress are reported to associated with the pathogenesis of anxiety, but the underlying brain mechanisms remain unclear. METHODS AND RESULTS Here, using a mouse model o...