Predicting Intratumoral Heterogeneity and Stratifying Prognostic Risk in Gastric Cancer Using a Histology-Based Pathomics-Deep Learning Fusion Model.
Intratumoral heterogeneity (ITH) is a fundamental driver of clonal evolution and therapeutic resistance in gastric cancer (GC). However, the clinical assessment of ITH remains limited by the high cost and technical complexity of multi-region and single-cell sequencing. This study aimed to develop a pathomics-deep learn...