Author

Shwetha Sreenivasan

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Open access Aug 2026

RheoScale 2.0: Revealing the hidden roles of protein positions via substitution patterns

A central challenge in molecular biology is understanding how amino acid substitutions modulate various features of protein function and stability. To illuminate the complexities of this relationship, high-throughput (HTP) assays are increasingly used to assess site-saturating mutagenesis libraries. A common downstream...

David H. Liu, Shwetha Sreenivasan, Carter J. Gray et al. · bioRxiv · 0 citations