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Author

Si-Dong Huang

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Review Open access Sep 2026

A therapeutic vulnerability linking MNK1/2 inhibition and G1/S cyclin-dependent kinase blockade in triple-negative breast cancer

It is demonstrated that MNK1/2 inhibition synergizes with CDK4/6 blockade suppresses TNBC cell growth, a synergy also observed in another independent TNBC cell line (SUM159) using a broader G1/S CDK (CDK2/4/6) inhibitor.

Qi-Yun Deng, Mehdi Amiri, A. Moshari et al. · 0 citations
Jul 2026

Abstract IA003: DICER1-related tumor predisposition: genotypes, phenotypes and mechanisms

It is demonstrated that inhibitors of MEK and CDK4/6 strongly suppressed tumour growth of DRTP PIS PDXs and induced upregulation of genes associated with neuronal differentiation can be used to induce neural differentiation and suppress growth of DRTP PIS.

W. Foulkes, Anne-Laure Chong, Hannah D. Hosein et al. · 0 citations

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