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Si-Ga Huang

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Sep 2026

Structural Mass Spectrometry Resolves the Conformational Dynamics of Semaglutide Oligomerization

Recent studies showed that several widely used glucagon-like peptide-1 receptor agonists (GLP-1RAs) can self-assemble into dynamic oligomeric species and ultimately less-regular, non-amyloid aggregates. While mature aggregates can be characterized by high-resolution microscopy methods, probing the conformational dyna...

Si-Ga Huang, Yu-Ye Zhou, Tin-yi Lui et al. · 0 citations

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