Open access
Oct 2026
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and tau pathology, with mTORC1 hyperactivation implicated in disease pathogenesis via suppression of autophagy. However, systematic evidence regarding its key upstream repressor, TSC1, in human AD brains remains limited....
Zheng-Zhao Liu, Yu-Chen Yu, Yu Wang et al.
· Frontiers in Aging Neuroscie... · 0 citations