MDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation.
Skin photoaging is mainly driven by chronic ultraviolet (UV) exposure and is closely associated with oxidative stress, DNA damage, cellular senescence, and extracellular matrix disruption. MDL800 is a selective allosteric activator of sirtuin 6 (SIRT6), but its role in UV-induced skin photoaging has not been investigat...