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Si-Meng Zhang

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Open access Sep 2026

Compartment-Specific Inhibition of Cytosolic Cathepsin B Mitigates Microglial Senescence in the Aging Brain.

Microglial senescence is a hallmark of brain aging, but how lysosomal dysfunction fuels their pro-aging activity remains unresolved. Here we identify cytosolic Cathepsin B (CatB) as a pivotal driver of microglial senescence. In aged mice and senescence-induced models, lysosomal membrane permeabilization releases CatB i...

Si-Meng Zhang, Chen Zhang, Jian Mao et al. · 0 citations

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