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Author

Si Wu

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Open access Sep 2026

Structural insights into target detection by the Serratia type III CRISPR complex and its deployment in SNP identification.

Type III CRISPR systems utilize a complex containing Cas10, additional Cas proteins and a crRNA to detect foreign transcripts. Upon detection, Cas10 synthesizes cyclic oligoadenylates (cOA), signaling molecules that coordinate interference by stimulating downstream enzymes with DNase, RNase, protease or other activitie...

Calvin C. Perdigao, L. Ajisafe, A. Sunny et al. · 0 citations
Sep 2026

Top-Down Proteomics Analysis of pg-Level Cell Lysate Using Spray-Capillary CE-FAIMS-MS

Capillary electrophoresis-mass spectrometry (CE-MS) is a promising technique for ultrasensitive top-down proteomics due to its high resolution and sensitivity compared with traditional liquid chromatography (LC)-based methods. However, CE-MS-based top-down proteomics of mass-limited samples remains challenging becaus...

Samina Anjum, Zhi-Tao Zhao, Kellye A. Cupp-Sutton et al. · 0 citations
Open access Sep 2026

ProteoformTracker: an interactive tool for planning proteoform detectability in top-down and middle-down proteomics

ProteoformTracker is an online web tool that prospectively models MS signal and evaluates the feasibility of using TDP/MDP to distinguish a target proteoform from related isoforms and the background proteome, and envisioned as a useful tool for users to plan TDP/MDP experiments targeting specific proteoforms.

Araf Mahmud, Zhi-Hao Zhang, Si Wu et al. · 0 citations

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