Type III CRISPR systems utilize a complex containing Cas10, additional Cas proteins and a crRNA to detect foreign transcripts. Upon detection, Cas10 synthesizes cyclic oligoadenylates (cOA), signaling molecules that coordinate interference by stimulating downstream enzymes with DNase, RNase, protease or other activitie...
Calvin C. Perdigao, L. Ajisafe, A. Sunny et al.· Journal of Biological Chemis...· 0 citations
Capillary electrophoresis-mass spectrometry (CE-MS) is a promising technique for ultrasensitive top-down proteomics due to its high resolution and sensitivity compared with traditional liquid chromatography (LC)-based methods. However, CE-MS-based top-down proteomics of mass-limited samples remains challenging becaus...
Samina Anjum, Zhi-Tao Zhao, Kellye A. Cupp-Sutton et al.· Journal of Proteome Research· 0 citations
ProteoformTracker is an online web tool that prospectively models MS signal and evaluates the feasibility of using TDP/MDP to distinguish a target proteoform from related isoforms and the background proteome, and envisioned as a useful tool for users to plan TDP/MDP experiments targeting specific proteoforms.
Araf Mahmud, Zhi-Hao Zhang, Si Wu et al.· bioRxiv· 0 citations
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