Open access
Aug 2026
The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs
ABSTRACT Thiol‐mediated uptake (TMU) is a powerful strategy for promoting the cellular uptake of nano‐drugs; however, the mechanochemical principles that coupled ligand reactivity, carrier mechanics, and receptor clustering remain poorly understood. Herein, the effect of carrier rigidity and cyclic disulfide reactivity...
Zhuang Zhang, Hui Wang, Hao Zhang et al.
· Advancement of science · 0 citations