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Si-Yuan Gong

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Open access Sep 2026

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation

Abstract Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury and is associated with mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and tubular cell apoptosis. Sigma-1 receptor (Sigma1R), an intracellular chaperone, helps maintain mitochondrial homeostasis an...

Si-Yuan Gong, Yong-Hong Xiong, Wen-Yuan Li et al. · 0 citations

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