Open access
Oct 2026
A synthetic PGC1α co-activator reprograms microglial immunometabolism to preserve cone function in retinal degeneration
Retinitis pigmentosa (RP) is genetically heterogeneous, yet initiating mutations converge on primary rod degeneration followed by cone dysfunction and loss. Activated microglia are implicated in this secondary phase, but whether selective immunometabolic reprogramming of microglia preserves retinal function remains unk...
T. Winogrodzki, Jayvin Hernandez-Reyes, Rajvir Solanky et al.
· bioRxiv · 0 citations