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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Siyuan Zheng

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2 papers indexed here

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Open access Oct 2026

Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors

Whole-genome doubling (WGD) occurs frequently in human cancer and influences tumor evolution, metastasis, and treatment response. Here, we integrate bulk, single-cell, and spatial data to dissect the subclonal dynamics of WGD. Single-cell data analysis shows that WGD cells are prevalent even in tumors that are classifi...

Fu-Nan He, M. Noureen, E. Dray et al. · 0 citations
Open access Aug 2026

EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells

SUMMARY Ewing sarcoma (EwS) is characterized by chimeric fusions such as EWSR1::FLI1. Chromosome gain or loss is prevalent in EwS, and this chromosome instability (CIN) phenotype correlates with poor treatment outcomes. We previously showed that CENP-A, a centromere-specific histone H3 variant, interacts with EWSR1 via...

R. Kitagawa, Ediri E Metitiri, Bin Yu et al. · 0 citations

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