Author

Si-Zhao Lu

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Open access Aug 2026

KLF4 in smooth muscle cell-derived progenitor cells is essential for angiotensin II-induced cardiac inflammation and fibrosis

BACKGROUND: Cardiac fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) material resulting in cardiac tissue scarring and dysfunction. While it is commonly accepted that myofibroblasts are the major contributors to ECM deposition in cardiac fibrosis, their origin remains controversial. Our g...

Si-Zhao Lu, Tysen Noble, J. Elkins et al. · Arteriosclerosis, Thrombosis... · 0 citations

Open access Jul 2026

A cross-model single-cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease

An integrated single-cell RNA sequencing atlas across mouse models of PKD is constructed, mapping changes in cell type composition, gene expression, and intercellular signaling networks across the whole atlas and within individual models.

S. Miller, Hua Zhong, Weidong Wu et al. · JCI Insight · 0 citations