Open access
Aug 2026
SLC25A1-targeted gene therapy attenuates liver fibrosis through NEDD4-mediated ubiquitination and degradation of PPARγ.
Findings establish the SLC25A1-regulated metabolic axis as a promising therapeutic target and offer a robust preclinical proof-of-concept for targeted gene therapies against liver fibrosis.
Shu-Qin Xue, Xiu-Juan Yin, Sicheng Shu et al.
· Pharmacological Research · 0 citations