Open access
Jul 2026
Bead-based RNA Detection with Cas13a: Multi-scale Design and Validation
A multi-scale analytical framework integrating nanoscale enzyme kinetics, microscale diffusion constraints, and macroscale assay parameters is presented that is used to develop a bead-based Cas13a assay where the bead becomes fluorescent when the target RNA for that bead is detected.
A. Bhuiya, Siddhansh Agarwal, Carlos F. Ng et al.
· bioRxiv · 0 citations