Siddharth Kumar

Quantitative correlation of spectroscopic signatures with ligand–protein interactions in anti-cancer drug Afinitor: an integrated experimental–computational study

A detailed molecular-level understanding of anticancer drugs is essential for improving therapeutic efficacy and guiding rational drug design. Everolimus (Afinitor), a clinically important inhibitor of the mammalian target of rapamycin (mTOR) pathway, is widely used in cancer therapy; however, a quantitatively grounded...